Chromosomal translocation detected by bcl‐1 and bcl‐2 rearrangement in low‐grade B‐cell lymphomas in a European population

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Abstract
Twenty‐nine cases of non‐Hodgkin's lymphoma of low‐grade malignancy in a European population were investigated for the presence of bcl‐2 and bcl‐1 gene rearrangement. The cases were classified according to the Kiel classification. It was shown that bcl‐2 gene rearrangements were exclusively confined to centroblastic‐centrocytic lymphomas. bcl‐1 rearrangements were found in two cases of chronic lymphocytic leukaemia. As the chromosomal translocation t(14;18) is reported to occur in up to 85% of follicular lymphomas, our results provide additional evidence that the differentiation of low‐grade B‐cell lymphomas according to the Kiel classification defines biologically distinct entities.