PERINEURIOMA (LOCALIZED HYPERTROPHIC NEUROPATHY)
- 1 January 1984
- journal article
- research article
- Vol. 108 (7) , 557-560
Abstract
Three patients with localized hypertrophic neuropathy (LHN) has a painless, slowly progressive mononeuropathy overy many years, resulting in severe focal neurologic deficit. Grossly, the affected nerves showed a fusiform enlargement. Histologically, there was loss of nerve fibers, disorganization of the fascicular pattern, and proliferation of elongated cells with whorl formation. These cells exhibited no immunoreactivity for S-100 protein, and ultrastructural features set them apart from Schwann''s cells. LHN is not a disorder caused by hyperplasia of Schwann''s cells but a benign peripheral nerve tumor of perineurial cell origin. Perineurial and Schwann''s cells may not derive from the same precursor element.This publication has 10 references indexed in Scilit:
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