Comparison of dihydrodiazepam enantiomers: Metabolism, serum binding and brain receptor binding
- 1 September 1980
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 36 (9) , 1031-1032
- https://doi.org/10.1007/bf01965950
Abstract
Dihydrodiazepam is a diazepam prodrug, as shown by its in vitro metabolism by rat and mouse liver and brain microsomal fractions, and its displacing activity on brain diazepam binding. The mechanism of bioactivation is discussed. Stereoselectivity of metabolism and of binding to specific benzodiazepine binding sites in brain synpatosomes and serum albumin were studied.Keywords
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