Neonatal myasthenia gravis
- 1 January 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 38 (1) , 138
- https://doi.org/10.1212/wnl.38.1.138
Abstract
Anti-acetylcholine receptor (AChR) antibody titers, toxin binding blocking antibody, functional activity of serum on rat myotube cultures, IgG subclasses, and clinical data were studied in relation to the onset of neonatal myasthenia gravis (NMG) in 30 children of myasthenic mothers. Fourteen had NMG, including 4 atypical cases. Anti-AChR antibody titer was the best indication of NMG onset. NMG in a previous baby was also predictive. Pattern of IgG subclasses, presence of toxin-binding blocking antibodies, and serum functional activity were less predictive, but cast light on the mechanism of anti-AChR antibody pathogenicity.This publication has 8 references indexed in Scilit:
- Neonatal myasthenia gravis: Clinical and immunological study of seven mothers and their newborn infantsJournal of Neuroimmunology, 1986
- Molecular distinction between fetal and adult forms of muscle acetylcholine receptorNature, 1986
- Role of acetylcholine receptor subunits in gating of the channelNature, 1985
- Newborn infants to myasthenic mothersNeurology, 1983
- Acetylcholine receptor antibodies in infants of mothers with myasthenia gravisNeurology, 1981
- Antiacetylcholine Receptor Antibody in Neonatal Myasthenia GravisArchives of Pediatrics & Adolescent Medicine, 1981
- SIGNIFICANCE IN NEONATAL MYASTHENIA GRAVIS OF INHIBITORY EFFECT OF AMNIOTIC FLUID ON BINDING OF ANTIBODIES TO ACETYLCHOLINE RECEPTORThe Lancet, 1979
- THE IMMUNOLOGICAL DEVELOPMENT OF THE HUMAN FETUSThe Journal of Experimental Medicine, 1965