Malignant hyperthermia: Molecular defects in membrane permeability
- 1 May 1985
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 41 (5) , 656-661
- https://doi.org/10.1007/bf02007707
Abstract
Malignant hyperthermia (MH), a genetically inherited disorder of skeletal muscle, is due to molecular defect in membrane permeability. The alteration in membrane permeability is suggested to be due to enhanced phospholipase A2 activity which is responsible for the increased level in sarcoplasmic Ca2+. The excess Ca2+ is responsible for muscle hyper-rigidity and enhanced rate of glycolysis, resulting in a rapid rate of lactic acid production and a low pH in MH muscle.Keywords
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