Antibacterial Chemotherapy Tests: Influence of Challenge Preparation and of Dosage Schedule on the in Vivo Effectiveness of a Bacteriostatic and a Bactericidal Antibiotic

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Abstract
The primarily bactericidal drug streptomycin was generally more active in vivo in relation to its in vitro endpoints than was the primarily bacteriostatic tetracycline. The bactericidal drug was more effective than the bacteriostatic one in preventing the recovery of the infecting organism Salmonella schottmuelleri from the blood of surviving mice. There were few recoveries from mice surviving intraperitoneal infection with Staphylococcus aureus. The effect of the treatment schedule on the intraperitoneal therapeutic endpoints was associated with the type of challenge preparation used and not with the infecting organism or the type of in vitro activity on the antibiotic agent.