INFLUENCE OF CHLORPROMAZINE ON THE REPLICATION OF INFLUENZA-VIRUS IN CHICK-EMBRYO CELLS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 26  (4) , 209-+
Abstract
Influence of chlorpromazine (CPZ) on the production of influenza virus was followed in chick embryo cell (CEC) monolayers. CPZ, which binds specifically to calmodulin (CaM), inhibited in concentration of 20-100 .mu.mol/l the activty of CaM-stimulated 3'', 5''-c''AMP phosphodiesterase. When administered together with the virus, CPZ in concentrations of 20-50 .mu.mol/l reduced virus yields by 2-3 log plaque-forming units. Addition of CPZ 15 min before or 1 h after influenza virus adsorption had no effect. The inhibitory action of CPZ was reversed by purified CaM. The adsorption of influenza virus to CEC or to erythrocytes was not affected. The participation of CaM on the mechanism of influenza virus penetration is discussed.