PHOSPHATE ACCUMULATION BY THE ISOLATED RENAL TUBULE AND THE EFFECTS OF PARATHYROID-HORMONE AND CYCLIC ADENOSINE-MONOPHOSPHATE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 96  (1) , 24-35
Abstract
The effects of metabolic and transport inhibitors and PTH [parathyroid hormone], c[cyclic]AMP, db[dibutyryl]cAMP and theophylline on Pi uptake by an isolated rat renal tubular preparation were investigated. Pi uptake by this preparation was a saturable process, was O2- and Na-dependent, was inactivated by heat-treatment and was inhibited by dinitrophenol, iodacetate, ouabain and a decrease in temperature from 37.degree. to 4.degree. C. PTH and cAMP stimulated Pi uptake by energy-dependent and ouabain-inhibitable mechanisms.