Solid‐phase synthesis of oligodeoxynucleotides containing 6‐O‐alkylguanosines

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Abstract
High‐quality oligodeoxynucleotides having an 6‐O‐alkyl‐2′‐deoxyguanosine (alkyl = methyl, ethyl, n‐propyl or n‐hexyl) residue at a predetermined position can be obtained via a solid‐phase approach using the respective 2‐cyanoethyl N,N‐diisopropylphosphoramidites of 5′‐O‐(4.4′‐dimethoxytrityl)‐protected 6‐O‐alkyl‐2′‐deoxyguanosines having a free exocyclic amino group, and 5′‐O‐(4‐4′‐dimethoxytrityl) N‐acyl‐protected (i.e., benzoyl and isobutyryl for dC/dA and dG, respectively) 2′‐deoxynucleosides.

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