Inhibition of Mouse Encephalomyelitis Virus, in vitro, by Certain Nucleoprotein Derivatives.
- 1 April 1952
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 79 (4) , 571-573
- https://doi.org/10.3181/00379727-79-19450
Abstract
Adenine, adenosine, cytidine, guanosine and thymine inhibit the propagation of Theiler''s GDVII strain of murine encephalomyelitis virus in tissue cultures of 1-day mouse brain. Guanine, uridine, uracil, guanylic or cytidylic acids did not inhibit. Various substituted nucleosides including amino-, chloro-, diazo-, formamido-, hydroxy- and methyluridine were inhibitory. Uridine partially reversed this inhibition. 5-Chlorouracil, ribosylthymine and glucosylthymine did not inhibit; 2,6-diaminopurine did. 5-Chlorouridine was not effective against this viral infection in mice.Keywords
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