Cytotoxic T-cell responses to H-Y: mapping of the Ir genes.

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Abstract
The secondary cytotoxic responses to the male specific antigen (H-Y) in mice show H-2 restrictions so that cytotoxic female cells must share K and/or D end antigen with the male target cells. The production of cytotoxic cells is under the control of Ir [immune response] genes, thus offering the possibility of studying the function of Ir genes in H-2-restricted cytotoxic responses. There are 2 kinds of Ir genes regulating this response; the dominant gene in the H-2b haplotype and complementary genes in other haplotypes. The dominant gene and some of the complementary genes were mapped: the dominant gene is in IAb, and in H-2k/H-2d complementation, the Ir genes are in ICk and ICd, and in H-2k/H-2s and H-2k/H-2q complementations, at least the H-2k gene is in IC.