CLINICAL EXPERIENCE WITH STREPTOKINASE AND STREPTODORNASE IN TUBERCULOSIS

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Abstract
Streptokinase and streptodornase are useful topical adjuncts in the surgical treatment of certain acute and chronic diseases. The properties of these compounds and the results of treatment have been reported in detail elsewhere.1 Streptokinase is a catalytic agent acting on a fibrin-lysing system present in the euglobulin fraction of human blood. The agent activates the fibrin-lysing system, which causes liquefaction of fibrin. Streptokinase also inhibits the change of fibrinogen to fibrin. Tests of streptokinase for protein give positive results. The substance is rendered inert by trypsin and activated papain, does not act upon casein, peptone, or gelatin, and can be isolated from the dissolved fibrin clot after completion of liquefaction. Streptokinase is antigenic, and an antikinase may develop in human beings as the result of antecedent hemolytic streptococcic infection or prolonged treatment with streptokinase. Streptodornase is an enzyme having the capacity to hydrolyze desoxyribose nucleoprotein. Kunitz2 has described