An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Top Cited Papers
- 14 September 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5537) , 2111-2114
- https://doi.org/10.1126/science.1061964
Abstract
The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)–related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.Keywords
This publication has 28 references indexed in Scilit:
- BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFFScience, 2001
- Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseasesArthritis & Rheumatism, 2001
- B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune ResponsesMolecular and Cellular Biology, 2001
- B Cell Development PathwaysAnnual Review of Immunology, 2001
- Identification and Characterization of a Novel Cytokine, THANK, aTNF Homologue That ActivatesApoptosis, Nuclear Factor-κB, and c-Jun NH2-Terminal KinaseJournal of Biological Chemistry, 1999
- Receptor Editing in B CellsPublished by Elsevier ,1999
- Identification of the Earliest B Lineage Stage in Mouse Bone MarrowImmunity, 1996
- Distinctive Developmental Origins and Specificities of Murine CD5+ B CellsImmunological Reviews, 1994
- Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ miceEuropean Journal of Immunology, 1991
- Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.The Journal of Experimental Medicine, 1991