Circulating Reticuloendothelial Depressing Substance following Thermal Injury and Intestinal Ischemia

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Abstract
Whether RES depressing substance is present in the circulation following thermal injury and intestinal ischemia was studied. Plasma extracts were prepared from blood collected from animals at 3 h after thermal injury or after 3 h of intestinal ischemia. RES depressing activity was assayed by measuring the colloidal carbon clearance rate in rats or mice following the injection of plasma extracts. Control animals never demonstrated the presence of RES depressing activity. Thermal injury in dogs and rats produced consistently detectable circulating levels of RES depressing activity. Acid hydrolysis of plasma extracts from thermally injured dogs destroyed the RES depressing activity. Intestinal ischemia in dogs resulted in detectable RES depressing activity in portal vein blood. An RES depressing substance may contribute to the RES depression which occurs following thermal injury and intestinal ischemia.