Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions
- 31 August 1994
- journal article
- review article
- Published by Elsevier in Journal of Pharmacological and Toxicological Methods
- Vol. 31 (4) , 177-186
- https://doi.org/10.1016/1056-8719(94)90001-9
Abstract
No abstract availableKeywords
This publication has 51 references indexed in Scilit:
- Persistent Impairment of Clomipramine Demethylation in Recently Detoxified Alcoholic PatientsTherapeutic Drug Monitoring, 1992
- Hyperinsulinaemia causes a preferential increase in hepatic p4501A2 activityBiochemical Pharmacology, 1992
- Comparative studies of N-hydroxylation and N-demethylation by microsomal cytochrome P-450Chemical Research in Toxicology, 1991
- Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiaeBiochemistry, 1990
- Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotypeClinical Pharmacology & Therapeutics, 1989
- Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramineEuropean Journal of Clinical Pharmacology, 1989
- High plasma concentrations of desmethylclomipramine after chronic administration of clomipramine to a poor metabolizerEuropean Journal of Clinical Pharmacology, 1987
- Purification of a desmethylimipramine and debrisoquine hydroxylating cytochrome P-450 from human liverBiochemical Pharmacology, 1986
- Electrochemistry of norcocaine nitroxide and related compounds: Implications for cocaine hepatotoxicityBiochemical and Biophysical Research Communications, 1985
- Relationship of N-demethylation of amiflamine and its metabolite to debrisoquine hydroxylation polymorphismClinical Pharmacology & Therapeutics, 1984