Cimetidine premedication in elective caesarean section

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Abstract
A single intramuscular injection of Cimetidine was compared to oral antacid premedication in 17 patients undergoing elective Caesarean section. Seven patients in the Cimetidine group and four in the antacid group had gastric volumes in excess of 50 ml after induction of anaesthesia, while two patients in each group had gastric pH less than 2.5 after induction. Cimetidine was as effective as antacid in raising gastric pH but neither was completely reliable. This study reconfirms the high gastric volumes in pregnant patients with the need for preventative measures against aspiration during the induction of anaesthesia. On a comparù la cimùtidine administrùe par voie intramusculaire à ľadministration orale ďun antacide en prùmùdication chez 19 patientes accouchùes par cùsarienne ùlective. Le volume du liquide gastrique a ùtù supùrieur à 50 ml chez sept des neuf patientes ayant reçu une dose de cimùtidine 30 minutes avant ľinduction, alors que cette situation se retrouvait chez quatre des huit patientes ayant reçu un antacide. La cimùtidine s’est avùrùe aussi efficace que ľantacide pour ùlever le pH du liquide gastrique, mais ni ľun ni ľautre n’ùtait entièrement fiable. Cette ùtude reconfirme la prùsence de volumes liquidiens gastriques ùlevùs chez les patientes enceintes et la nùcessitù ďutiliser des mesures pour prùvenir ľaspiration au cours de ľinduction de ľanesthùsie.

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