(11; 14) Translocation in three boys with acute lymphoblastic leukemia of T-cell immunophenotype
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in Annals of Hematology
- Vol. 52 (1) , 45-50
- https://doi.org/10.1007/bf00320141
Abstract
Three boys, 12, 15 and 5 years old are presented with acute lymphoblastic leukemia resp. Non-Hodgkin's lymphoma with leukemic transformation. Blast cells could be characterized as being of T-cell origin. Hand mirror variant was the predominant morphologic feature of the blast cells in two patients. Chromosome analysis of the leukemic blast cells revealed a pseudodiploid (modal chromosome number =46) karyotype in two patients and a pseudotetraploid (modal chromosome number =92) in one patient. A chromosome translocation (11; 14) with breakpoints at (p 13; q 13) (within the human T-cell receptor α chain locus!) was found in the leukemic cells of all three cases plus an additional t (7; 9) (q 22; p 13) in one patient.Keywords
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