CD45R gives immunofluorescence and transduces signals on mouse T cells

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Abstract
The expression of CD45R on mouse T cells has been studied. This antigen is expressed on the two higher molecular weight bands of CD45 (or T200) and in mouse it is currently used as a marker of B cells (B220). Here we confirm that CD45R is expressed on some mouse T cell clones. We show that a small but measurable proportion of mouse spleen and peripheral blood lymphocyte T cells gives positive immunofluorescence with B220. Also CD45R‐specific antibodies increase the proliferation response to phytohemagglutinin up to 3‐fold, thus confirming that CD45R molecules transduce a signal into mouse T cells.