INDUCTION OF ALTERED GLOBIN SYNTHESIS IN HUMAN IMMATURE ERYTHROCYTES INCUBATED WITH RIBONUCLEOPROTEIN
- 1 January 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (1) , 68-80
- https://doi.org/10.1073/pnas.48.1.68
Abstract
Altered globin production can be induced in human immature erythrocytes when incubated with nucleo-protein preparations isolated from genetically different marrow. The altered globin production is dependent upon the presence of both intact RNA and protein in the nucleoprotein preparation. DNA is not required for this effect. Information necessary for abnormal hemoglobin formation is present in the marrow nucleoprotein but not in that derived from spleen.Keywords
This publication has 20 references indexed in Scilit:
- THE OCCURRENCE OF NATURAL DNA-RNA COMPLEXES IN E. COLI INFECTED WITH T2Proceedings of the National Academy of Sciences, 1961
- Incorporation of Heterologous Deoxyribonucleic Acid into Mammalian CellsScience, 1961
- Nuclear Function and Nuclear-Cytoplasmic InteractionsAnnual Review of Physiology, 1960
- Genetic activity of deoxyribonucleic acid in the reconstitution of biosynthetic pathways.1959
- Chromatography of hemoglobin types on carboxymethylcellulose.1958
- A new technique for differentiation of hemoglobin.1957
- A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acidBiochemical Journal, 1956
- The relationship of ribonucleic acid to the in vitro incorporation of radioactive glycine into the proteins of reticulocytesBiochimica et Biophysica Acta, 1954
- NUCLEIC ACID CONTENT OF RETICULOCYTES AND ITS RELATION TO UPTAKE OF RADIOACTIVE LEUCINE IN VITROJournal of Biological Chemistry, 1952
- Iron Metabolism. Heme Synthesis in Vitro by Immature ErythrocytesScience, 1949