Factors Influencing Development of Insulin-Induced Hypoglycemic Convulsions in the Rabbit

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Abstract
Of a group of 12 rabbits treated with "convulsive" doses of insulin, only 7 responded with convulsions. An attempt made to assay metabolic factors responsible for reactivity yielded negative results. Except for the occurrence of convulsions the reactors differed significantly from the non-reactors only in initial body wts., and could not be distinguished from the non-reactors in the glycemic response to the 1st insulin injn., in response to epinephrine admn., or in liver glycogen. A significant difference in depth of hypoglycemia after the 2nd insulin injn., was related to an unexplained increase in insulin sensitivity in the reactors, which increase did not occur in the non-reactors. The data indicate that more was involved in the elicitation of convulsions than the blood glucose level and/or its rate of fall.

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