MECHANISM OF THE ACTION OF THYROXINE AND ASCORBIC ACID DEFICIENCY ON THE TENSILE STRENGTH OF HEALING WOUNDS

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Abstract
In guinea pigs, treatment with thyroxine causes a moderate reduction in the S35-sulphate incorporation into wound tissue but this effect is not demonstrable in skin. In scorbutic animals, thyroxine administration causes a much greater decrease in S35 sulphate incorporation in both wound and skin tissue. It is suggested that the inhibitory effect of thyroxine on wound healing may have caused a thyroxine-induced change in sulpho-mucopolysaccharides.