Ovarian cancer. Effective treatment after alkylating-agent failure

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Abstract
Combination chemotherapy consisting of hexamethylmelamine and cisplatin, alone or with doxorubicin HCl, was given to 27 patients with advanced ovarian cancer who had disease progression with therapy including alkylating agents. Eighteen (67%) had greater than 50% regression of measurable disease or disease that could be evaluated but not measured, for a projected median duration of 7 mo. The projected median survival for all patients is 9 mo. from the time of entry into the study and 33 mo. from the time of diagnosis of ovarian cancer. The treatment could be readily administered on an outpatient basis with a regimen of hydration and diuresis that nearly completely prevented Pt-induced renal tubular damage. Myelosuppression was severe in 11 patients (40%), but there were no treatment-related deaths. Agents of such high activity should be considered as components of initial therapy for stage III and IV cancers.