Structure and organization of genes for sporozoite surface antigens
- 13 November 1984
- journal article
- research article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 307 (1131) , 129-139
- https://doi.org/10.1098/rstb.1984.0114
Abstract
The major surface antigen (circumsporozoite-protein) of the sporozoite stage of Plasmodium knowlesi has been cloned and characterized. The gene is notable for the presence of a 36 base pair unit repeated in tandem 12 times. These repeats may function at the DNA level in regulating gene expression and at the protein level in providing multiple copies of a single epitope (repitope) as part of a protein designed to evade and decoy the immune system.This publication has 12 references indexed in Scilit:
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