Étude de la réponse à l'amputation des phalanges chez la souris : rôle morphogénétique des épithéliums, stimulation de la chondrogenèse

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Abstract
The third phalanx of the mouse regenerates through epimorphosis, as it does in Urodela: dedifferentiation, growth, and redifferentiation. This capability would be due to the local persistence of embryonic characteristics in the dermis and the skeleton and to the morphogenetic action of developing epithelia. The amputation of the second phalanx results in scarring and in the formation of bony callosities. When stimulated by extracts of scarring epithelium or by growth hormone, these callosities, which constitute a model of tissue regeneration, can proliferate as do the chondroblastic regenerates in Anura.[Journal translation]