Pharmacokinetics and Tissue Distribution of Recombinant Human Alpha A, D, A/D(Bgl), and I Interferons and Mouse Alpha-Interferon in Mice

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Abstract
The pharmacokinetics and tissue distribution in mice of several recombinant human alpha-interferons [rHuIFN-αA, D, I,and A/D(Bgl)] as well as natural mouse alpha-interferon (MuIFN-α) were assessed following single intravenous injections. The serum profiles of rHuIFN-αA, rHuIFN-αD, rHuIFN-αA/D(Bgl), and MuIFN-α were similar, whereas those following rHuIFN-αI showed a much longer terminal elimination phase. Differences in elimination half-life, volume of distribution, and total body clearance between these IFNs were observed. There was appreciable uptake of IFN in the kidney: the amount of each interferon per gram of tissue in the kidney ranges from 1 to 9 times the amount found in the serum. The greatest uptake appeared with rHuIFN-αD, followed by rHuIFN-αA, rHuIFN-αA/D(Bgl), and MuIFN-α. The only exception was rHuIFN-αI which showed no uptake into the kidney.