THE THERAPEUTIC EFFICIENCY OF DIETHYLSTILBESTROL ESTERS

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Abstract
The comparison of the activity of various estrogens for therapeutic standardization has until recent years depended for the most part on results obtained with laboratory animals. It has been frequently pointed out, however, that assays of estrogens vary extremely in the hands of investigators using different species of animals as well as various strains of the same animal. It is obvious that such a basis for the comparison of estrogens leads to confusion, and a number of investigators have recently suggested that estrogens be assayed directly in studies on man. In this regard changes in the endometrium or vaginal smear of menopausal women have been used for determining the potency of several estrogens.1 We have pointed out that the use of the endometrial biopsies for assaying purposes is awkward and not sufficiently accurate, since a significant percentage of women in the menopause have varying degrees of endometrial development even without

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