The Effect of an Adrenal Inhibitor (SU 4885) on Gastric Secretion in Dogs
Open Access
- 1 December 1960
- Vol. 1 (4) , 345-350
- https://doi.org/10.1136/gut.1.4.345
Abstract
There is considerable evidence that the adrenocortical steroids potentiate both human and canine gastric secretion. In this study, the action of the adrenocortical inhibitor, SU 4885, has been observed in dogs having separated pouches of the stomach. No effect was noted on the secretory responses to meat, histamine, or mecothane when the drug was given by single intravenous injection. However, the 24-hour output of acid was inhibited when the drug was given orally for a period of 10 to 14 days. While this effect may be due to the ability of the drug to inhibit adrenocortical function, there is no positive supporting evidence.Keywords
This publication has 13 references indexed in Scilit:
- The Effects of Corticotrophin and Corticoids on Secretion from Denervated Gastric Pouches in DogsGut, 1960
- INHIBITION OF ALDOSTERONE SECRETION AND MODIFICATION OF ELECTROLYTE EXCRETION IN MAN BY A CHEMICAL INHIBITOR OF 11β-HYDROXYLATION*†Journal of Clinical Investigation, 1959
- An inhibitor of adrenal steroid 11-hydroxylation.1959
- Crystallization of ChlorophyllsScience, 1958
- ALTERATIONS OF ADRENAL STEROID PATTERNS IN MAN RESULTING FROM TREATMENT WITH A CHEMICAL INHIBITOR OF 11 βHYDROXYLATIONJournal of Clinical Endocrinology & Metabolism, 1958
- New Amphenone analogs as adrenocortical inhibitorsCellular and Molecular Life Sciences, 1958
- The secretory response of the denervated gastric pouch to prolonged massive cortisone administration.1958
- Duodenal ulcer and the hypophysis-adrenal stress mechanism.1956
- PEPTIC ULCER AND THE ADRENAL STRESS SYNDROMEArchives of Surgery, 1952
- A method for estimating peptic activity in gastric contentsBiochemical Journal, 1948