In Vivo Angiogenic Activity of Interleukins
- 1 April 1990
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 108 (4) , 573-576
- https://doi.org/10.1001/archopht.1990.01070060121061
Abstract
• Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus. A constant and reproducible neovascular stimulus was observed with 5 ng per implant of recombinant human interleukin 1 alpha or 100 ng per implant of recombinant human interleukin 1 beta. At these concentrations, neither tumor necrosis factor nor interleukin 2 induced any neovascular stimulus. These data are interpreted as an indication for the possible role of interleukin 1 in angiogenesis of ocular (and other) tissues. As interleukin 1 is produced by various cells, it is hypothesized that this molecule may be the "unitarian angiogenic factor."This publication has 18 references indexed in Scilit:
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