ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS
Open Access
- 1 February 1971
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 133 (2) , 275-288
- https://doi.org/10.1084/jem.133.2.275
Abstract
Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.Keywords
This publication has 6 references indexed in Scilit:
- Choriocarcinoma: Transfilter Stimulation of Vasoproliferation in the Hamster Cheek Pouch—Studied by Light and Electron Microscopy2JNCI Journal of the National Cancer Institute, 1968
- The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumourBritish Journal of Cancer, 1968
- H-2 components and cellular membranes: distinctions between plasma membrane and endoplasmic reticulum governed by the H-2 region in the mouse.1967
- Tumor Behavior in Isolated Perfused OrgansAnnals of Surgery, 1966
- A new method for the isolation of ribonucleic acids from mammalian tissuesBiochemical Journal, 1956
- HETEROLOGOUS TRANSPLANTATION OF MAMMALIAN TUMORSThe Journal of Experimental Medicine, 1941