Intracellular Stimulation of an Identified Neuron Evokes Cardioacceleratory Peptide Release
- 24 May 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 228 (4702) , 1013-1015
- https://doi.org/10.1126/science.4001929
Abstract
The central nervous system of the tobacco hawkmoth, Manduca sexta , is known to contain two cardioacceleratory peptides (CAP's), both of which function in vivo as cardioregulatory neurohormones. Intracellular electrical stimulation of a single abdominal ganglion neuron evokes the release of CAP-like bioactivity. This stimulation-evoked bioactivity is destroyed by prior treatment with protease. The possibility that intracellular stimulation of a CAP-containing neuron synaptically activated additional spiking neurons is eliminated.Keywords
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