Effects of CIS‐platinum on embryonal carcinoma cell lines in vitro
- 15 July 1984
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 34 (1) , 133-139
- https://doi.org/10.1002/ijc.2910340123
Abstract
Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis-platinum (cis-diamine-dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non-seminomatous germ-cell tumors to cis-platinum therapy.This publication has 45 references indexed in Scilit:
- Significance of the ?maturation? of metastases from germ cell tumours after intensive chemotherapyHistopathology, 1984
- Histone variants and chromatin structure during sea urchin developmentDevelopmental Biology, 1980
- Embryotoxicity and teratogenicity of Cis-diamminedichloroplatinumCellular and Molecular Life Sciences, 1979
- Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysisCell, 1978
- HeLa Cultures DefinedScience, 1976
- BENIGN TRANSFORMATION OF TESTICULAR CARCINOMA BY CHEMOTHERAPYThe Lancet, 1975
- ABSENCE OF SEROLOGICALLY DETECTABLE H-2 ON PRIMITIVE TERATOCARCINOMA CELLS IN CULTURETransplantation, 1974
- Expression of liver phenotypes in cultured mouse hepatoma cells: Synthesis and secretion of serum albuminDevelopmental Biology, 1973
- Established cell line of urinary bladder carcinoma (T24) containing tumour‐specific antigenInternational Journal of Cancer, 1973
- Effect of halogenated pyrimidines and thymidine on growth of L-cells and a subline lacking thymidine kinaseExperimental Cell Research, 1964