EFFECTS OF TREATMENT WITH CYCLOPHOSPHAMIDE ON HORMONE-DEPENDENT AND HORMONE-INDEPENDENT TUMOR-CELLS IN TRANSPLANTED GR MOUSE MAMMARY-TUMORS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 61  (5) , 861-867
Abstract
Previous studies indicated that hormone responsive mammary tumors of GR mice are mixed populations of hormone dependent and autonomous cells. It was investigated whether these 2 cell types differ in susceptibility to cytostatic treatment. Experiments in which cyclophosphamide was injected into tumor-bearing mice did not reveal significant differences in percentage of inhibition between hormone dependent, hormone responsive and hormone independent tumors. The estrogen and progesterone receptor contents of the residual tumor masses after cyclophosphamide treatment were about the same as those of untreated tumors. When the cytostatically treated tumors were transplanted, the degree of hormone responsiveness of the transplants did not differ from that of transplants derived from untreated tumors, nor did their hormone receptor contents. These results indicate that hormone dependent and autonomous cells of GR mouse mammary tumors are inhibited to similar extents by cyclophosphamide. The possible significance of these for combined endocrine therapy and chemotherapy is discussed.

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