Molecular recognition in aqueous solution: an estimate of the intrinsic binding energy of an amide–hydroxy hydrogen bond
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1295-1297
- https://doi.org/10.1039/C39910001295
Abstract
The intrinsic binding energy of an amide–hydroxy hydrogen bond [NHCO ⋯ HO] has been estimated (ca.– 12 kJ mol–1 at 293 K); the major contribution to this value appears to be entropic, hydrogen bond formation being driven by the release of ordered water from the carbonyl group.Keywords
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