HIGH-DOSE METHOTREXATE AND ADRIAMYCIN IN OSTEOGENIC-SARCOMA - THE CHILDRENS-HOSPITAL-OF-PHILADELPHIA STUDY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 5  (1) , 3-8
Abstract
From 1975 through 1979, 25 patients with osteosarcoma received therapy with vincristine, high-dose methotrexate, citrovorum factor and Adriamycin. Five patients had metastases prior to receiving chemotherapy, and 11 of the remaining 20 nonmetastatic patients received preoperative or preirradiation chemotherapy. Chemotherapy caused objective tumor regression in 1 of 5 patients with metastases and 1 of 11 with measurable primaries. All 5 patients with metastatic disease died 7-16 mo. from diagnosis. Of the 20 nonmetastatic patients, 4 did not have primary amputations: all died. Of 16 patients with primary amputations, 6 are alive relapse-free 24-86 mo. from diagnosis, and 10 are dead. The actuarial survival of 36% is not statistically different from that of historical control groups or from that of concurrent control groups treated with surgery alone. However, because most adjuvant chemotherapy studies have involved few patients, 36% survival is not statistically different from the 50-70+% survival reported in previous studies. These data fail to demonstrate that the adjuvant chemotherapy has improved the survival rate of children with osteosarcoma.