Reusable Polymer-Supported Catalyst for the [3+2] Huisgen Cycloaddition in Automation Protocols
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- 25 March 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (8) , 1689-1692
- https://doi.org/10.1021/ol060283l
Abstract
A polymer-supported catalyst for Huisgen's [3+2] cycloaddition reaction between azides and alkynes was prepared from copper(I) iodide and Amberlyst A-21. This catalyst was then used in an automated synthesis of 1,4-disubstituted 1,2,3-triazoles giving access to these products in good yields. The catalyst has shown good activity, stability, and recycling capabilities.Keywords
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