The effects of 5-bromodeoxyuridine (BrdU) on morphogenesis of the early chick embryo
- 1 March 1974
- journal article
- Published by Springer Nature in Wilhelm Roux' Archiv für Entwicklungsmechanik der Organismen
- Vol. 174 (1) , 102-106
- https://doi.org/10.1007/bf00577060
Abstract
The effects of BrdU (3×10−4 M) on morphogenesis of the chick embryo explanted at the definitive streak stage and cultured for 24 hours were studied. Compared to controls treated embryos often showed (1) an open neural tube and (2) less numerous somites. Heart development was not significantly affected by BrdU. The damage caused by BrdU was not permanent, i.e., the embryos retained the ability to undergo fairly normal morphogenesis when, after 4–5 hours of BrdU treatment, they were subcultured on a medium with excess thymidine.Keywords
This publication has 13 references indexed in Scilit:
- Action of 5-Bromodeoxyuridine on the Induction of Haemoglobin Synthesis in Mouse Leukaemia Cells resistant to 5-BUdRNature New Biology, 1973
- Studies on the Effects of Bromodeoxyuridine (BUdR) on DifferentiationDifferentiation, 1973
- News, opinion and lettersDevelopmental Biology, 1972
- Preferential inhibition by 5-bromodeoxyuridine of the synthesis of tyrosine aminotransferase in hepatoma cell culturesJournal of Molecular Biology, 1971
- Effects of actinomycin D on explanted early chick embryos.1970
- 5-Bromodeoxyuridine-Induced Differentiation of a NeuroblastomaProceedings of the National Academy of Sciences, 1970
- INHIBITION OF MYOBLAST FUSION AFTER ONE ROUND OF DNA SYNTHESIS IN 5-BROMODEOXYURIDINEThe Journal of cell biology, 1970
- The loss of phenotypic traits by differentiated cells, V. The effect of 5-bromodeoxyuridine on cloned chondrocytes.Proceedings of the National Academy of Sciences, 1968
- The effects of D- and L-threo-chloramphenicol on the early development of the chick embryoDevelopment, 1965
- The mitotic behavior of chromosomes in echinoderm eggs following incorporation of bromodeoxyuridineExperimental Cell Research, 1964