Abstract
Fuller and Griffiths first demonstrated the feasibility of obtaining an infrared spectrum directly on an intact Empirin® tablet using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). We have found that several modifications of this method are necessary to obtain useful spectra for most other tablets. Applications of these modified procedures to the analysis of several tablets of forensic science interest are presented, and the results are compared to those obtained by conventional means. The direct analysis of some capsule contents and other powders is also presented and discussed.