Potentiation of Adrenergic Cardiovascular Effects of Two Quaternary Nicotine Analogues by Reserpine

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Abstract
Euler, U. S. V. and N.‐Å. Persson.Potentiation of adrenergic cardiovascular effects of two quaternary nicotine analogues by reserpine. Acta physiol. scand. 1970.78. 459–464.The quaternary nicotine analoguesiso‐monomethylnicotinium bromide (IMN) and l‐methyl‐3‐(pyrrolidinomethyl)‐pyridinium bromide (MPP) exert only weak effects on the blood pressure and heart rate of the spinalized, vagotomized and adrenalectomized cat in doses of 0.5–1 mg/kg i.v. After a dose of 0.25 mg/kg of reserpine i.v. the effect is strongly potentiated but almost abolished by desipramine. Whereas the pressor effect of nicotine is annulled by hexa‐methonium, the action of the two quaternary compounds is markedly potentiated. The effects of IMN and MPP are also enhanced by previous infusion of prenylamine 0.25 mg/min/kg. It is concluded that reserpine allows IMN and MPP to get access to noradrenaline stores through the axonal membrane and cause a release of neurotransmitter.

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