On the Mechanism of Depletion of Noradrenaline Stores by Iso‐Monomethylnicotinium Bromide

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Abstract
The quaternary nicotine analogue iso‐monomethylnicotinium bromide (IMN) inhibits the uptake of noradrenaline (NA) in the perfused guinea‐pig heart without causing any change in the distribution between the particulate and soluble fractions of the NA taken up. In the isolated perfused cat spleen IMN increases the resting outflow of NA, and the NA overflow response to nerve stimulation, while that to tyramine (TA) is reduced. IMN does not affect release or uptake of NA in isolated splenic nerve granules, or the formation of NA from tyrosine in this system.It is suggested that IMN causes depletion of NA stores both by releasing NA, probably from extragranular sites, and by inhibiting reuptake of the NA released.