Uptake of Noradrenaline in the Isolated Perfused Rat Heart after Depletion with Decaborane
- 1 May 1968
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 73 (1-2) , 128-138
- https://doi.org/10.1111/j.1748-1716.1968.tb04090.x
Abstract
After depletion of noradrenaline (NA)in vivowith decaborane, isolated perfused rat hearts rapidly take up NA to approximately the normal content from a perfusion medium containing NA 10‐7–10‐6M.The NA uptake is inhibited to varying degrees by cocaine, desmethyl‐imipramine, phenoxybenzamine, reserpine, iso‐methyl nicotinium bromide, prenylamine and by certain sympathomimetic and other autonomic drugs.The decaborane‐depleted heart appears to be a useful preparation for the study of the bulk uptake of NA.Keywords
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