Inhibitory Action of Adrenergic Blocking Agents on Catecholamine Release and Uptake in Isolated Nerve Granules

Publisher Website
Google Scholar
Abstract
A series of adrenergic α‐and β‐blockers have been found to decrease the release rate of nor‐adrenaline from a suspension of bovine splenic nerve granules incubated in phosphate buffer at pH 7.5. The same blockers also inhibited the uptake of noradrenaline in partially depleted nerve granules in the presence of ATP—Mg++. It is tentatively suggested that the interactions of the adrenergic blocking agents with uptake mechanisms for noradrenaline in the nerve granules and at the receptor level in effector cells involve certain common features.
Keywords