Faecal Blood Loss During Administration of Acetylsalicylic Acid, Ketoprofen and Two New Ketoprofen Sustained-Release Compounds

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Abstract
The influence of 1-wk treatment with acetylsalicylic acid, ketoprofen, ketoprofen sustained-release capsules (Biovail capsules) and ketoprofen sustained-release tablets (IBP tablet) [antiinflammatory agents] on gastrointestinal bleeding was investigated in 41 healthy male volunteers by radiochromium assay. The physiological fecal bleeding was 0.10-0.90 ml/day (99% confidence limits). Apparently fecal bleeding during treatment with acetylsalicylic acid medication was greater than bleeding during medication with ketoprofen capsules in equipotent dosage, the latter being in turn causing significantly more bleeding than during medication with the newly developed Biovail capsules. The most modest fecal bleeding (0.8 ml/day) was seen with IBP tablets.