Evidence for formation of DNA-bound protonated porphyrin adducts even at pH 7
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 1547-1548
- https://doi.org/10.1039/c39930001547
Abstract
An absorption and a positive circular dichroism (CD) band in the Soret region at 451 nm and a fluorescent emission band at 725 nm provide compelling evidence that the binding of a tentacle tetracationic porphyrin, meso-tetrakis[4-{(3-trimethylaminopropyl)oxy}phenyl]porphine (TθOPP), to calf thymus (CT) DNA leads to extensive porphyrin protonation, even at pH 7, and that a protonated porphyrin can form DNA adducts with a binding mode different from that of the unprotonated species.Keywords
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