Über Steroid-Konjugate in Plasma, XVIII. In-vivo-Biogenese und Metabolismus von3H- und35S-markierten C19-Steroid-sulfatiden
- 1 January 1966
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 344 (Jahresband) , 159-162
- https://doi.org/10.1515/bchm2.1966.344.1-3.159
Abstract
Following the i. v. injection of [7[alpha]-3H]androstenolone-[35S]sulfate (3H/35S = 3.3) in a normal female subject, the fraction of steroid sulfatides in plasma (3H/35S = 2.6) yielded 4 fractions of steroid sulfates with a comparable H3/S35 ratio (1.3-2.4) upon repeated chromatography. From these fractions androst-5-ene-3[beta],16[alpha],17[beta]-triol, 3]beta],17[beta]-dihydroxy-androst-5-ene-16-one, 3[beta],16[alpha]-dihydroxy-androst-5-ene-17-one, androst-5-ene-3[beta],17[beta]-diol, 3[beta]-hydroxy-androst-5-ene-17-one, 3[alpha]-hydroxy-5[beta]-androstane-17-one, 3[alpha]-hydroxy-5[alpha]-androstane-17-one and androst-4-ene-3,17-dione could be isolated and tentatively identified. These findings suggest a direct metabolism of suloconjugated androstenolon to androsterone and 5[beta]-androstan-3[alpha]-ol-17-one with androstenedione enolsulfate as possible intermediate.This publication has 6 references indexed in Scilit:
- ÜBER LIPOPHILE STEROID-KONJUGATEActa Endocrinologica, 1966
- Über Steroid-Konjugate in Plasma, XVII. Isolierung und Charakterisierung lipophiler Steroid-Konjugate aus Nebennierenrindengewebe, Plasma und LiquorHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1966
- Über Steroid-Konjugate in Plasma, XV. In-vivo-Biogenese von C19-Steroid-sulfatidenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1965
- Hydrolysis of Conjugated 17-Ketosteroids1Journal of Clinical Endocrinology & Metabolism, 1963
- Die harnausscheidung von 7-hydroxy-dehydroepiandrosteronsulfatClinica Chimica Acta; International Journal of Clinical Chemistry, 1962
- PAPER PARTITION CHROMATOGRAPHY OF C19- AND C21-KETOSTEROIDSJournal of Biological Chemistry, 1953