Chromosome 15 trisomy in spontaneous and carcinogen‐induced murine lymphomas of B‐cell origin

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Abstract
G‐banding analyses of 14 independently derived B‐cell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous B‐cell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogen‐induced primary B‐cell leukemias, trisomy 15 was the dominating change. Taken together with the previously demonstrated importance of chromosome 15 trisomy for T‐cell leukemogenesis and of the 12;15 translocation in plasmacytogenesis in the mouse, it appears likely that the distal part of chromosome 15 carries a cluster of genes, perhaps a supergene region, that may play an important role in the differentiation and/or the normal responsiveness of various lymphoreticular cell types to growth control.