Immune Complexes in Human Melanoma: A Consequence of Deranged Immune Regulation
- 29 June 1976
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 5 (6-7) , 845-859
- https://doi.org/10.1111/j.1365-3083.1976.tb03034.x
Abstract
Circulating immune complexes were detected in 62 individuals with malignant melanoma by precipitation with isolated human C1q and polyclonal rheumatoid factors. In 56 patients the C1q deviation assay showed low to moderate levels of complexes, with increased amounts with advancing stage of disease. Both heavy (>19S) and intermediate (7S to 19S) varieties were present, and complexes containing tumor antigen‐antibody or antibody‐ anti‐antibody were identified. Complexes were found in the kidneys of one patient with malignancy and the nephrotic syndrome and in two further patients with melanoma in whom there were DO clinical manifestations of nephrosis. Serial determinations in 51 patients showed slow cyclic variations in the levels of complexes and fluctuations in response to therapy. The coexistence of anti‐antibodies, immune complex disease, and anergy in melanoma patients may indicate a deranged immune regulation consequent to chronic antigenic stimulation by the tumor.Keywords
This publication has 36 references indexed in Scilit:
- CIRCULATING IMMUNE COMPLEXES AND SYMPTOMS IN HODGKIN'S DISEASEThe Lancet, 1976
- IMMUNOSTIMULANT THERAPY WITH LEVAMISOLE FOR RHEUMATOID ARTHRITISThe Lancet, 1976
- Effects of levamisole and imidazole on lymphocyte proliferation and cyclic nucleotide levelsCellular Immunology, 1975
- Circulating immune complexes in schistosomiasis due to Schistosoma mansoni.BMJ, 1975
- PRESENCE AND POSSIBLE ROLE OF ANTI-IgG ANTIBODIES IN HUMAN MALIGNANCYThe Lancet, 1974
- Requiem for the Nature ConservancyNature, 1972
- Possible Explanation for Loss of Detectable Antibody in Patients with Disseminated Malignant MelanomaNature, 1971
- NEPHROTIC SYNDROME IN MALIGNANT DISEASE OF NON-RENAL ORIGINThe Lancet, 1971
- Transplantation Immunity : Localization in Mouse Serum of Antibodies Responsible for Haemagglutination, Cytotoxicity and EnhancementNature, 1966
- A Method of Trace Iodination of Proteins for Immunologic StudiesInternational Archives of Allergy and Immunology, 1966