Current Views on Formation of Thyroid Hormones

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Abstract
Iodide peroxidase — its possible ferriporphyrin nature. Alexander68, 76 , 77 made an important contribution toward understanding the mechanism of thyroid-hormone formation by demonstrating the ability of salivary and thyroid homogenates to function as iodide peroxidases. His test system demonstrates the augmented consumption of H2O2 by these homogenates when iodide is present. The H2O2 is presumably used to peroxidate iodide. The concept is deceptively simple, and has not been disputed to date. De Groot, Thompson and Dunn78 observed that iodide also acts in this system to protect the iodide peroxidase-tyrosine iodinase complex from inactivation by H2 . . .