Effectiveness of Simplified Dosage Schedules on the Management of Ambulant Epileptic Patients

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Abstract
The effect of dosage schedules on plasma drug levels was evaluated in 2 groups of ambulant epileptic patients, whose treatment with diphenylhydantoin (DPH) or phenobarbital (PB) had been simplified by reducing the daily frequency of the dosage regimens. Although the patients received the same milligram per kilogram daily of DPH or PB during the study, the mean plasma levels of the 2 drugs were significantly higher during the less-frequent dosage regimens. Twice-daily dosage schedules of DPH and once-daily dosage schedules of PB are apparently advantageous over more complicated dosage schedules resulting in a higher compliance among ambulant epileptic patients.