Retinoblastoma, chromosome 13, and in vitro cellular radiosensitivity
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 24 (3) , 176-184
- https://doi.org/10.1159/000131374
Abstract
Five diploid fibroblast strains from patients with deletions mapping in the long arm of chromosome 13 and three strains bearing partial trisomies of chromosome 13 were assayed for clonogenic survival following X-irradiation. Results of these experiments suggest the existence of a region on 13ql4 which is related to increased sensitivity to cell killing in vitro by X-rays. This locus seems to be distinct from but close to the retinoblastoma locus, which has been associated with the same band.Keywords
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