Microangiographic Visualization of Blood Distribution in Intact and Regenerated Rat Adrenals Before and During Cold Stress

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Abstract
Intraglandular blood volume and distribution was investigated in intact rat adrenals and in 30-day regenerated mesenteric autografts or enucleated glands before and during exposure to cold stress using Thorotrast contrast medium. In the absence of stress, blood vessels of intact adrenals were more completely filled with contrast medium than were those of regenerated adrenocortical tissue. After exposure to stress, intact glands showed no obvious increase in Thorotrast filling, whereas regenerated tissues exhibited considerable increase. In intact glands, the major concentration of contrast medium was shifted from the central to the peripheral regions as the result of stress. Thorotrast was homogeneously dispersed, however, throughout the entire mass of both regenerated transplants or enucleated glands under all conditions. These findings present additional evidence for a vascular abnormality in regenerated adrenocortical tissue which prevents normal adjustment of inflow to outflow during stress and may result partly from a deficiency of vasoactive neurohormones.